Are granulosa cell tumors cancerous?

Ovarian granulosa cell tumor (GCT) is a malignant tumor with slow progression. The recurrence of granulosa cell tumor often happens after 5 years, leading to a ‘forgotten tumor’ by the patient.

Is adult granulosa cell tumor a cancer?

Adult-type granulosa cell tumor is a clinically and molecularly unique subtype of ovarian cancer. These tumors originate from the sex cord stromal cells of the ovary and represent 3-5% of all ovarian cancers. The majority of adult-type granulosa cell tumors are diagnosed at an early stage with an indolent prognosis.

Can granulosa cell tumors spread?

Although most recurrences are within 10 years after the initial diagnosis, there are reports of recurrence after 10 years. So, patients should be kept on a long-term follow-up protocol even if the primary tumor is occult. Spread is largely within the pelvis and the lower abdomen.

What are the symptoms of granulosa cell Tumour?

These may include increased linear growth, breast enlargement, clitoral enlargement, pubic hair development, increased vaginal secretions, and vaginal bleeding. In a few instances, patients present with virilizing symptoms as a result of testosterone production by the tumor cells.

THIS IS IMPORTANT:  Can TB mimic lung cancer?

Is granulosa cell tumor cancer hereditary?

Adult granulosa cell tumors can occur in familial clusters and could potentially be hereditary.

What is granulosa cancer?

Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. This type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. Granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman’s body.

Are granulosa cell tumors benign?

GCTs are thought to be tumors of low malignant potential. Most of these tumors follow a benign course, with only a small percentage showing aggressive behavior, perhaps due to early stage at diagnosis. Metastatic disease can involve any organ system, although tumor growth usually is confined to the abdomen and pelvis.

What is granulosa cell?

The granulosa cell (GC) is a critical somatic component of the ovary. It is essential for follicle development by supporting the developing oocyte, proliferating and producing sex steroids and disparate growth factors.

How often do granulosa cell tumors recur?

Results: A total of 97 patients with primary GCT of the ovary were identified. The median follow-up period was 88 months (range 6–498). Of these, 33 patients had at least one episode of disease recurrence, with a median time to recurrence of 53 months (range 9–332).

Do granulosa cells produce progesterone?

The granulosa cells respond to follicle stimulating hormone (FSH) and produce estrogen. Granulosa cells in the large pre-ovulatory follicle also respond to LH and produce progesterone (Webb et al., 2004; Skinner, 2005).

THIS IS IMPORTANT:  What procedures does a medical oncologist do?

What is the tumor marker for granulosa cell tumor?

We conclude that granulosa-cell tumors produce inhibin. Since serum inhibin levels reflect the size of the tumor, measurements of inhibin can be used as a marker for primary as well as recurrent disease.

What type of bodies are found in granulosa cell tumor?

H&E stain. Granulosa cell tumours are tumours that arise from granulosa cells. They are estrogen secreting tumors and present as large, complex, ovarian masses. These tumours are part of the sex cord-gonadal stromal tumour or non-epithelial group of tumours.

What do granulosa cells secrete?

Granulosa cells of the ovulatory follicle are the major and virtually only source of estradiol in the follicular phase of the ovarian cycle and secrete estrogens in response to FSH.