Can chemotherapy cause mitral valve regurgitation?

Severe mitral regurgitation is a yet unreported manifestation of chemotherapy-induced cardiotoxicity which needs prompt attention.

Can chemo cause a leaky heart valve?

Chemotherapy, especially with anthracyclines, has been associated with left ventricular dysfunction and valve disease. It has been assumed that chemotherapy-induced myocardial depression and heart failure was the cause of the valve dysfunction (secondary or functional valve regurgitation).

What is the most common cause of mitral regurgitation?

It is caused by disruption in any part of the mitral valve (MV) apparatus. The most common etiologies of MR include MV prolapse (MVP), rheumatic heart disease, infective endocarditis, annular calcification, cardiomyopathy, and ischemic heart disease.

Can chemotherapy affect your heart?

Traditional and novel chemotherapy agents can damage the heart or peripheral blood vessels, or cause problems with clotting or blood lipids. Some serious cardiovascular effects occur while the chemotherapy is being given; others appear long after cancer has become a distant memory.

What drugs cause mitral valve disease?

People who take drugs containing ergotamine (Cafergot, Migergot) and similar medicines for migraines or who take cabergoline have an increased risk of mitral regurgitation. Similar problems were noted with the appetite suppressants fenfluramine and dexfenfluramine, which are no longer sold.

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What chemo drugs affect the heart?

Chemotherapy drugs that can cause heart damage include:

  • anthracycline drugs such as doxorubicin (Adriamycin), daunorubicin (Cerubidine, daunomycin) and epirubicin (Pharmorubicin)
  • cisplatin.
  • carboplatin (Paraplatin, Paraplatin AQ)
  • paclitaxel (Taxol)
  • cyclophosphamide (Procytox)

Is heart Damage From Chemo reversible?

Cardiotoxicity can be defined as a direct effect of chemotherapy resulting in cardiac dysfunction which may lead to reversible/irreversible heart failure.

Can mitral regurgitation go away?

Mitral regurgitation may begin suddenly. This often occurs after a heart attack. When the regurgitation does not go away, it becomes long-term (chronic). Many other diseases or problems can weaken or damage the valve or the heart tissue around the valve.

Can stress cause mitral valve regurgitation?

Rarely, a person may need surgery or other aggressive therapies. Moreover, the symptoms may be very episodic, and come in waves and then disappear for some time. Symptoms of mitral valve prolapse may be aggravated by pregnancy, stress, pregnancy, fatigue, menstrual cycles (menstruation), or other illnesses.

How do you fix mitral regurgitation?

In mitral valve repair, the surgeon removes and repairs part of the damaged mitral valve to allow the valve to fully close and stop leaking. The surgeon may tighten or reinforce the ring around a valve (annulus) by implanting an artificial ring (annuloplasty band).

How can I protect my heart during chemo?

Stay healthy after treatment

  1. Get to and stay at a healthy weight.
  2. Get regular exercise.
  3. Eat a healthy diet, with an emphasis on fruits, vegetables, and whole grains.
  4. Get recommended cancer screenings.
  5. Create a survivorship care plan.
  6. Keep your follow-up appointments.
  7. Take care of your emotional health.
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What are the symptoms of cardiac toxicity?

Symptoms of cardiac toxicity may include:

  • Chest pain.
  • Heart rhythm changes (arrhythmia).
  • Fatigue.
  • Shortness of breath.
  • Weight gain.
  • Swelling.

Can chemo cause rapid heartbeat?

Several drugs used to treat some of the most common forms of cancer, like breast cancer, leukemia and lymphoma, can affect how the heart functions. In some cases, this can lead to heart failure, elevated blood pressure, rapid heartbeat and heart attack.