Frequent question: Is it common for renal cell carcinoma to metastasize?

Patients with renal cell cancer (RCC) develop metastatic spread in approximately 33% of cases.

Where does renal cell carcinoma typically metastasize to?

RCC typically metastasizes to the lung, bone, lymph nodes, liver, adrenal glands, and brain (Fig 2) (23), although practically any organ may be affected.

Is Kidney Cancer likely to metastasize?

Like any type of cancer, kidney cancer can spread beyond its original location. This does not always occur, but when it does, the condition is known as metastatic kidney cancer. In most cases, the term “metastatic kidney cancer” is used to refer to cancer that has spread to distant organs, such as the: Lungs.

Which are the most common sites of metastases from renal cell carcinoma?

The most common sites of metastases were: lung (71%), lymph nodes (49%), bone (36%), liver (21%), adrenal (9%), brain (9%), pancreas (5%), pleura (4%) and thyroid (0.6%).

How common is RCC metastasis?

Approximately one-third of patients with renal cell carcinoma (RCC) present with metastatic disease, and amongst those patients with localized disease, a substantial proportion will recur [1].

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What is metastatic clear cell renal cell carcinoma?

Metastatic clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer. Localized ccRCC has a favorable surgical outcome. However, one third of ccRCC patients will develop metastases to the lung, which is related to a very poor outcome for patients.

Does renal cell carcinoma spread fast?

RCC is a fast-growing cancer and often spreads to the lungs and surrounding organs.

Is renal cell carcinoma aggressive?

Collecting duct carcinoma and renal medullary carcinoma are aggressive types of kidney cancer, which doctors find challenging to treat. People with these types of cancer may have a poorer prognosis than people with other types.

Is metastatic renal cell carcinoma hereditary?

Renal cell cancer that affects multiple generations of a family is called hereditary renal cell cancer. Hereditary renal cell cancer is rare and accounts for only 5% to 8% of all renal cell cancers. It is usually linked to a hereditary syndrome.

Does renal cell carcinoma metastasis to the brain?

Background: Brain metastases (BM) are frequently observed in advanced renal-cell carcinoma (RCC). Historically these individuals have been excluded from clinical trials, but recently, with better local control, many can receive aggressive therapy after treatment.

Does RCC metastasis to brain?

Brain metastases in renal cell carcinoma (RCC) are reported in around 10% of patients1,2 and are considered to have a very poor prognosis of around 10 months.

How often does renal cell carcinoma recur?

The aggressive and often insidious nature of renal cell carcinoma (RCC) is reflected by recurrence rates of 20% to 40% after nephrectomy for clinically localized disease.

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Does renal cell carcinoma spread to the liver?

Renal cell cancer can spread to your liver. The liver filters toxins out of your blood and produces bile, a digestive fluid. Cancer in the liver can block the flow of blood and bile. It can lead to symptoms like appetite loss, weight loss, jaundice, nausea, and vomiting.

Does RCC metastasis to liver?

RCC patients develop metastases at various sites, including the lungs, lymph nodes, bone, brain and liver and their prognosis depends on the metastatic site. The frequency of liver metastasis (LM) in RCC patients is lower compared to that of metastasis to other sites, such as the lungs, lymph nodes and bone.