How long can you live with splenic marginal zone lymphoma?

The median overall survival in most series is about ten years and 70% of the patients can remain treatment free for five years. 17, 36, 53 There is no survival benefit for the association of chemotherapy with splenectomy,17 although some studies report increases in overall response rates.

Is splenic marginal zone lymphoma aggressive?

Aggressive variant of splenic marginal zone lymphoma (AV-SMZL) is a very rare disease that is often associated with TP53 mutations and has a poor prognosis.

Can you die from marginal zone lymphoma?

Survival in patients with MALT lymphomas varied depending on the site of origin, with a worse prognosis noted in those with gastrointestinal and pulmonary locations of origin (5-year incidence rate of lymphoma-related death, 9.5%-14.3%) compared with ocular, cutaneous, and endocrine sites (4.5%-7.8%; P < . 0001).

Can you cure splenic marginal zone lymphoma?

The most common treatment for splenic MZL is antibody therapy such as rituximab. This is often given on its own for splenic MZL. It can be very effective. You might have an initial course of rituximab to put your lymphoma into remission, followed by maintenance therapy to make your remission last as long as possible.

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Can you live a long life with SMZL?

Patients with SMZL often have an indolent course with median life expectancy greater than 10 years. However, about a quarter of patients have a more aggressive course, with disease progression and death within the first few years after diagnosis (Arcaini et al, 2006).

Can marginal zone lymphoma go into remission?

Relapsed or refractory nodal marginal zone lymphoma

It is common for nodal MZL to come back (relapse) after successful treatment. You can usually have more treatment to give another period of remission. This approach can often control the lymphoma for many years.

What stage is lymphoma in the spleen?

Stages of non-Hodgkin lymphoma may also include E and S. “E” stands for extranodal, and means the cancer is found in an area or organ other than the lymph nodes or has spread to tissues beyond, but near, the major lymphatic areas. “S” stands for spleen and means the cancer is found in the spleen.

Can you live 20 years with lymphoma?

Most people with indolent non-Hodgkin lymphoma will live 20 years after diagnosis. Faster-growing cancers (aggressive lymphomas) have a worse prognosis. They fall into the overall five-year survival rate of 60%.

What is the survival rate of marginal zone lymphoma?

evaluated the relative survival of MZL patients. The 5-year relative survival rates (adjusted to age, sex and race) for patients with EMZL, SMZL and NMZL were 88.7%, 79.7% and 76.5%, respectively (11). However, a subset of patients exhibits a more aggressive disease course and succumbs early to their disease (12,13).

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How does marginal zone lymphoma progress?

Marginal zone lymphoma (MZL) develops slowly and, in most cases, it responds well to treatment (remission). However, this is an indolent lymphoma, and this means that it often relapses (comes back). If the lymphoma does relapse it can usually be treated again to keep it under control.

Can an enlarged spleen cause death?

The more severe the spleen injury, the more guarded the outcome. The risk of complications appears to be greatest in people over age 55. Deaths caused by splenic rupture are possible and do still occur, even at the top trauma centers. You can live without a spleen.

Can SMZL spread?

SMZL can sometimes spread to the bone marrow, a soft tissue inside of certain bones. Cells in the bone marrow make new blood cells. If cancer spreads to the bone marrow, it can crowd out the body’s healthy blood cells, causing cytopenia (low blood cell counts).

Can an enlarged spleen go back to normal size?

What Is the Prognosis for Enlarged Spleen? Depending upon the cause, the enlarged spleen may return to normal size and function when the underlying disease is treated or resolved. Commonly, in infectious mononucleosis, the spleen returns to normal as the infection gets better.