Is thrombocytosis a sign of cancer?

Researchers have found evidence to suggest that thrombocytosis is a strong predictor of cancer, particularly lung and colorectal cancer. The team therefore believes patients with thrombocytosis should be evaluated for an underlying malignancy, as such investigation could speed up cancer diagnosis and save lives.

Is thrombocytosis a form of cancer?

Essential Thrombocythemia (ET)

Is one of a related group of blood cancers known as “myeloproliferative neoplasms” (MPNs) in which cells in the bone marrow that produce the blood cells develop and function abnormally.

What cancers can cause thrombocytosis?

Thrombocytosis is an adverse prognostic factor in many types of cancer. These include breast cancer, ovarian and other gynecologic cancers, renal cell carcinoma and lung cancers.

Is thrombocytosis serious?

Primary thrombocytosis, or essential thrombocythemia, can cause serious bleeding or clotting complications. These can usually be avoided by maintaining good control of the platelet count with medications. After many years of having the disease, however, bone marrow fibrosis (scarring) can develop.

How high are platelets in cancer?

A raised platelet count (thrombocytosis) measuring >400 × 109/l is associated with high cancer incidence. It is uncertain whether platelet counts at the upper end of the normal range (high-normal: 326–400 × 109/l) are also associated with cancer.

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How long can you live with thrombocytosis?

The life expectancy of patients with essential thrombocytosis (primary thrombocythemia) is nearly that of the healthy population. Median survival is approximately 20 years. For patients younger than age 60 years, median survival is 33 years.

Which cancers cause high platelet count?

What cancers cause a high platelet count?

  • Lymphoma.
  • Breast cancer.
  • Lung cancer.
  • Ovarian cancer.
  • Gastrointestinal cancer.

What are the symptoms of thrombocytosis?

Symptoms of thrombocythemia include:

  • Blood clots in arteries and veins, most often in the hands, feet, and brain.
  • Bruising easily.
  • Bleeding from the nose, gums, and GI (gastrointestinal) tract.
  • Bloody stools.
  • Bleeding after injury or surgery.
  • Weakness.
  • Headache and dizziness.
  • Swollen lymph nodes.

Does lymphoma cause thrombocytosis?

The incidence of thrombocytosis in lymphomas seems to be similar to that seen in other malignancies and because of this we conclude that a high platelet count cannot be used to distinguish malignancies.

What is the most common cause of thrombocytosis?

Essential thrombocythemia (ET) was the most common cause of primary thrombocytosis. Among secondary, non-infectious etiologies, tissue damage was the most common, followed by malignancy and iron-deficiency anemia. The most common infectious causes of thrombocytosis were soft-tissue, pulmonary and GI infections.

What autoimmune disease causes high platelets?

Hughes syndrome, or antiphospholipid antibody syndrome (APS), is an autoimmune condition that causes thickening of the circulating blood. The immune system produces abnormal blood proteins called antiphospholipid antibodies, which cause blood platelets to clump together.

What happens if platelet count is too high?

A high platelet count can cause blood clots to develop spontaneously. Normally, your blood begins to clot to prevent a massive loss of blood after an injury. In people with primary thrombocythemia, however, blood clots can form suddenly and for no apparent reason. Abnormal blood clotting can be dangerous.

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