What cancers did vinblastine work best on?

What Vinblastine Is Used For: This drug is given to treat Hodgkin lymphoma, non-Hodgkin’s lymphoma, testicular, breast, lung (Non-small cell lung cancer), head and neck, and bladder cancers, melanoma, soft tissue sarcoma, Kaposi’s sarcoma, mycosis fungoides (t-cell lymphoma), and choriocarcinoma.

What cancer does vinblastine treat?

Vinblastine is used in combination with other chemotherapy drugs to treat Hodgkin’s lymphoma (Hodgkin’s disease) and non-Hodgkin’s lymphoma (types of cancer that begin in a type of white blood cell that normally fights infection), and cancer of the testicles.

Why is vinblastine used?

Vinblastine is used to treat cancer. It works by slowing or stopping the growth of cancer cells.

Why is vinblastine an effective anticancer drug?

How vinblastine works. Vinblastine works by stopping the cancer cells from separating into 2 new cells. So it blocks the growth of the cancer.

Is vinblastine is used in acute lymphocytic leukemia?

Vinblastine is used mainly for the treatment of generalized Hodgkin’s disease, and non-Hodgkin’s lymphomas. Vincristine is used principally in the treatment of acute lymphocytic leukaemia in children. It has other applications for lymphomas, small-cell lung cancer, cervical and breast cancers.

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Which type of cancers are vinblastine and vincristine used to treat?

This drug is given to treat Hodgkin lymphoma, non-Hodgkin’s lymphoma, testicular, breast, lung (Non-small cell lung cancer), head and neck, and bladder cancers, melanoma, soft tissue sarcoma, Kaposi’s sarcoma, mycosis fungoides (t-cell lymphoma), and choriocarcinoma.

When was vinblastine first used?

Vinblastine was isolated in 1958. An example of a natural herbal remedy that has since been developed into a conventional medicine, vinblastine was originally obtained from the Madagascar periwinkle. It is on the World Health Organization’s List of Essential Medicines.

Vinblastine.

Clinical data
ATC code L01CA01 (WHO)
Legal status

Which stage of the cell does vinblastine interfere with?

Vinblastine is cell cycle phase specific; it binds to microtubular proteins in the mitotic spindle, thereby preventing cell division during metaphase. It also interferes with amino acid metabolism by inhibiting glutamic acid utilization and preventing purine synthesis, citric acid cycle, and urea formation.

When was vinorelbine launched?

Vinorelbine was invented by the pharmacist Pierre Potier and his team from the CNRS in France in the 1980s and was licensed to the oncology department of the Pierre Fabre Group. The drug was approved in France in 1989 under the brand name Navelbine for the treatment of non-small cell lung cancer.

What is vinblastine and curcumin?

Curcumin, a major component of curry powder, which is a natural polyphenol product extracted from rhizoma curcumae longae, interacts with a specific binding site on microtubules. Vinblastine is an antitumor drug that induces microtubule depolymerization.

How does vincristine and vinblastine work?

1 Vinblastine, Vincristine, and Vinorelbine

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These compounds have cell cycle-specific activity in the M phase, which is consistent with their ability to inhibit tubulin polymerization and prevent formation of the mitotic spindle. In this manner, they induce a terminal mitotic arrest that ultimately leads to cell death.

How was vinblastine discovered?

JACALYN DUFFIN

Noble was recognized for “his discovery of “vinblastine”‘ (VLB) a drug derived irom the Madagascar periwinkle plant (Vinca mm, now called Catharanthis mm); Beer, “for isolating’ it in 1958.

Why is etoposide called VP 16?

Etoposide was first synthesized in 1966 and U.S. Food and Drug Administration approval was granted in 1983. The nickname VP-16 likely comes from a compounding of the last name of one of the chemists who performed early work on the drug (von Wartburg) and podophyllotoxin.