What increases a patient’s risk for diarrhea following chemotherapy?

The use of high-dose regimens (eg, bolus FU plus high-dose leucovorin) and combination regimens (eg, CPT-11 plus bolus FU/leucovorin) is associated with a higher incidence of chemotherapy-induced diarrhea.

What causes diarrhea in chemo patients?

A weakened immune system due to cancer treatment can cause a higher risk for an infection which may cause diarrhea, too. Diarrhea that’s not treated or managed well can lead to dehydration and malnutrition.

What chemo drugs cause diarrhea?

Certain chemotherapy drugs are also known to cause diarrhea.

These include:

  • irinotecan (Camptosar)
  • 5-fluorouracil (Adrucil, 5-FU)
  • methotrexate.
  • docetaxel (Taxotere)
  • cisplatin (Platinol AQ)
  • dactinomycin (Cosmegen, actinomycin-D)
  • doxorubicin (Adriamycin)
  • arsenic trioxide.

How do you prevent chemo induced diarrhea?

How to Minimize or Avoid Chemotherapy-Induced Diarrhea:

  1. Drink plenty of clear fluids (8-10 glasses per day). Examples: Gatorade®, broth, Jello®, water, etc.
  2. Eat small amounts of soft bland low fiber foods frequently. …
  3. Avoid foods such as:

Is Diarrhoea a side effect of chemotherapy?

Some chemotherapy drugs irritate the lining of your digestive system. So diarrhoea is a common side effect. It usually comes on in the first few days after each treatment.

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What are the main causes of diarrhea?

What causes diarrhea?

  • Infection by bacteria.
  • Infections by other organisms and pre-formed toxins.
  • Eating foods that upset the digestive system.
  • Allergies and intolerances to certain foods (Celiac disease or lactose intolerance).
  • Medications.
  • Radiation therapy.
  • Malabsorption of food (poor absorption).

How is chemo induced diarrhea treated?

Based on evidence from well-controlled clinical trials, the opioid loperamide (4-mg initial dose followed by 2 mg every 4 hours) was recommended as the standard first-line therapy for chemotherapy-induced diarrhea.

Can chemotherapy cause bowel problems?

Some chemotherapy drugs, pain medicines and anti-nausea drugs can cause constipation or diarrhoea. Tell your doctor or nurse if your bowel habits have changed. Some people experience ongoing bowel problems after cancer treatment.

Why do you experience unpleasant side effects from chemotherapy?

Why does chemo cause side effects? Cancer cells tend to grow fast, and chemo drugs kill fast-growing cells. But because these drugs travel throughout the body, they can affect normal, healthy cells that are fast-growing, too. Damage to healthy cells causes side effects.

Can fluorouracil cause diarrhea?

The following side effects are common (occurring in greater than 30%) for patients taking Fluorouracil: Diarrhea. Nausea and possible occasional vomiting. Mouth sores.

Why does fluorouracil cause diarrhea?

Approximately 10 percent of patients being treated with FU have decreased expression of the enzyme lactase in their intestinal brush border, leading to lactose intolerance and causing osmotic diarrhea [6,7].

Can Taxol cause diarrhea?

Usually temporary occurring 2 to 3 days after Taxol, and resolve within a few days. Peripheral neuropathy (numbness and tingling of the hands and feet) Nausea and vomiting (usually mild) Diarrhea.

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What is refractory diarrhea?

Refractory diarrhea is a paraneoplastic syndrome of NB and is rare. Patients aged 1-3 years who present with chronic intractable diarrhea should be followed closely. Intractable diarrhea, hypokalemia, and dysplasia are the initial clinical manifestations. Increased VIP is characteristic of this disease.