What is carcinosarcoma cancer?

Listen to pronunciation. (KAR-sih-noh-sar-KOH-muh) A malignant tumor that is a mixture of carcinoma (cancer of epithelial tissue, which is skin and tissue that lines or covers the internal organs) and sarcoma (cancer of connective tissue, such as bone, cartilage, and fat).

Is carcinosarcoma cancer curable?

The cause of ovarian carcinosarcoma is not yet understood. Treatment usually consists of surgery to remove the tumor and chemotherapy . The chance of recovery and long-term survival ( prognosis ) is poor, with a reported 5-year survival rate of about 28%.

What is the survival rate for carcinosarcoma?

Reported five-year survival rates are between 30-40%. About 35% of carcinosarcomas are not confined to the uterus at diagnosis with corresponding median survival of 21 months.

How aggressive is carcinosarcoma?

Carcinosarcoma is aggressive type of tumour; extra-uterine spread is very common and generally carries a poor prognosis. The prognosis depends on the extent of the tumour at the time of primary surgery.

Is carcinosarcoma rare?

With an incidence of 2/100,000 females and a 5 years Survival at stage IV of 0%, it is an uncommon type of cancer with a very poor prognosis.

Does anyone survive carcinosarcoma?

The five-year disease-free survival (DFS) for all patients was 52% (95% CI 38.6–65.4%). A significant difference was seen in DFS of patients diagnosed with FIGO I–II and FIGO III–IV disease [72.4%; 95% CI 55.4–89.5%, and 20.6%; 95% CI 8.9–32.4%, respectively (p = 0.000)].

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How is carcinosarcoma treated?

Surgery is the primary treatment for uterine carcinosarcoma (UCS). Lymphadenectomy should be performed for staging purposes in tumors apparently confined to the uterus. Most studies found that lymphadenectomy is of therapeutic value.

What causes carcinosarcoma?

No clear etiology is known. However, accumulation of genetic mutations could be a factor. A history of exposure to irradiation of pleomorphic adenoma has been reported. The reported interval between the irradiation and the onset of carcinosarcoma varies from 1 to 36 years.

Is carcinosarcoma hereditary?

Conclusion: The loss of MLH1 protein expression suggests the germline mutation contributed to the development of the carcinosarcoma. Hereditary nonpolyposis colorectal cancer should be included in the differential diagnosis of persons with uterine carcinosarcoma when noted within a family history suspicious for HNPCC.

What does survival rate of 5 years mean?

The percentage of people in a study or treatment group who are alive five years after they were diagnosed with or started treatment for a disease, such as cancer. The disease may or may not have come back.

What is Stage 4 Carcinosarcoma?

Stage 4 cancer is sometimes referred to as metastatic cancer, because it often means the cancer has spread from its origin to distant parts of the body. This stage may be diagnosed years after the initial cancer diagnosis and/or after the primary cancer has been treated or removed.

How long can you have sarcoma without knowing?

It would appear that some people are quite happy to live with asymptomatic lumps for up to 5 or more years and our experience shows that most of these patients will have been re-assured by one or more doctors during this time. A long duration of symptoms has been shown to correlate weakly with good prognosis.

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Where is Carcinosarcoma located?

Carcinosarcomas are rare tumors, and can arise in diverse organs, such as the skin, salivary glands, lungs, the esophagus, pancreas, colon, uterus and ovaries.