What is luminal B cancer?

Luminal B breast cancer is hormone-receptor positive (estrogen-receptor and/or progesterone-receptor positive), and either HER2 positive or HER2 negative with high levels of Ki-67. Luminal B cancers generally grow slightly faster than luminal A cancers and their prognosis is slightly worse.

Is it better to be HER2 negative or positive?

HER2-positive cancer tends to be poorer in terms of prognosis than HER2-negative cancer because: It grows faster. It is more likely to spread to the lymph nodes fast. It is at least two times more likely to return than HER2-negative tumors.

Can luminal A breast cancer be cured?

Luminal A breast cancer grows very slowly and doesn’t often spread to other cells. Women with luminal A breast cancer have the best chance for a cure and least chance of cancer coming back than any other type of breast cancer.

What is the most common type of breast cancer?

Invasive ductal carcinoma (IDC), also known as infiltrating ductal carcinoma, is cancer that began growing in a milk duct and has invaded the fibrous or fatty tissue of the breast outside of the duct. IDC is the most common form of breast cancer, representing 80 percent of all breast cancer diagnoses.

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What are the two major subtypes of breast cancer?

About 85 percent of breast cancers are ductal carcinomas, while 11.4 percent are lobular carcinomas, according to a study published in the Annals of Medicine and Surgery. More than three-quarters of lobular carcinomas fall into the luminal A and triple-negative tumor category.

What does a high ki67 mean?

A staining process can measure the percentage of tumor cells that are positive for Ki-67. The more positive cells there are, the more quickly they are dividing and forming new cells. In breast cancer, a result of less than 10% is considered low, 10-20% borderline, and high if more than 20%.

Is HER2 inherited?

A genetic test can tell you if you have any mutations in genes that are related to an increased risk of breast cancer. It’s important to know that genetic testing is most helpful when you have a strong family history of either breast or ovarian cancer or a personal history of breast cancer.

What is the difference between luminal A and luminal B breast cancer?

Luminal A cancers are low-grade, tend to grow slowly and have the best prognosis. Luminal B breast cancer is hormone-receptor positive (estrogen-receptor and/or progesterone-receptor positive), and either HER2 positive or HER2 negative with high levels of Ki-67.

Why is it called luminal breast cancer?

The luminal cancers, luminal A and luminal B, so called because they are characterized by expression of genes also expressed by normal breast luminal epithelial cells, have overlap with ER-positive breast cancers.

Is luminal A invasive?

Invasive breast cancers are classified by morphology: ductal, lobular, tubular, mucinous, medullary, papillary, metaplastic, and others. Breast cancer subtypes are determined by gene profiling: luminal A, luminal B, normal, HER2+, and basal-like.

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What is the most treatable form of breast cancer?

Ductal Carcinoma In Situ is very early cancer that is highly treatable, but if it’s left untreated or undetected, it can spread into the surrounding breast tissue.

What is the most aggressive cancer?

Lung cancer is the most aggressive form of cancer. Smoking and tobacco use are the major causes of it. Low-dose CT scans, which can detect cancer earlier, have improved survival rates for those with lung cancer, even among heavy smokers.

What is the easiest breast cancer to treat?

Invasive breast cancers are staged I through IV, with stage I being the earliest stage and easiest to treat, while stages II and III represent advancing cancer, with stage IV representing breast cancer cells that have spread (metastasized) to distant organs like the bones, lungs, or brain.