What types of cancer does trastuzumab treat?

Herceptin is the brand name of a medicine called trastuzumab. It’s used to treat some types of breast cancer, oesophageal cancer and stomach cancer.

Is trastuzumab effective on all breast cancer patients?

Trastuzumab is a model of targeted therapy that offers significant clinical benefit selectively in patients with HER2-overexpressing cancers; however, trastuzumab alone or in combination with cytotoxic therapy yields no response for many patients, and indeed, the majority of patients with advanced breast cancer develop …

What cancers are HER2 positive?

Bladder carcinomas, gallbladder, extrahepatic cholangiocarcinomas, cervical, uterine, and testicular cancers showed HER2 positivity rates of 12.4, 9.8, 6.3, 3.9, 3.0, and 2.4 %, respectively. HER2 overexpression and/or amplification is frequently found across tumor types.

Is Herceptin better than chemotherapy?

Patients treated with Herceptin had a 33% reduced risk of death compared to those treated with chemotherapy only. Rates of severe cardiotoxicity occurred in approximately 4% of patients treated with Herceptin in the B-31 trial and approximately 3% of patients treated with Herceptin on the N9831 trial.

What is the treatment after trastuzumab?

Neratinib is used to treat early-stage breast cancer after a woman has completed one year of trastuzumab, and it is usually given for one year. It can also be given along with the chemo drug capecitabine to treat people with metastatic disease, typically after at least 2 other anti-HER2 targeted drugs have been tried.

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How many Herceptin treatments do I need?

If you’re having trastuzumab to treat primary breast cancer after surgery it’s usually given for one year (around 18 cycles). If you are having trastuzumab before surgery you will usually have four to six cycles.

Is it good or bad to be HER2-positive?

About 25% of breast cancers are HER2-positive. HER2-positive cancers are a mix of good and bad news. The bad news is the tumors tend to grow more aggressively than those without the HER2 receptor. The good news is that like ER/PR-positive cancers, medicines can switch the HER2 growth receptor off.

Is HER2 inherited?

HER2-positive breast cancer is not inherited. Instead, it’s considered a somatic genetic mutation. This type of mutation occurs after conception. Having a close relative with HER2-positive breast cancer does not increase your risk for breast cancer or HER2-positive breast cancer.

What does her 2 positive mean?

HER2-positive breast cancer is a breast cancer that tests positive for a protein called human epidermal growth factor receptor 2 (HER2). This protein promotes the growth of cancer cells. In about 1 of every 5 breast cancers, the cancer cells have extra copies of the gene that makes the HER2 protein.

What is the difference between trastuzumab and trastuzumab emtansine?

Trastuzumab alone stops growth of cancer cells by binding to the HER2 receptor, whereas trastuzumab emtansine undergoes receptor-mediated internalization into cells, is catabolized in lysosomes where DM1-containing catabolites are released and subsequently bind tubulin to cause mitotic arrest and cell death.

How effective is trastuzumab?

A study of more than 4000 patients, published in 2014, showed that adding trastuzumab to chemotherapy led to a 37% relative improvement in overall survival, increasing 10-year survival from 75.2% to 84%. The 10-year disease-free survival rate increased from 62.2% to 73.7%. All patient subgroups benefited.

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Is trastuzumab an immunotherapy?

These are active specific immunotherapy with Theratope and passive immunotherapy targeting the HER-2 receptor with trastuzumab (Herceptin). Trastuzumab has a proven efficacy as monotherapy as well as in combination with chemotherapeutic agents in HER-2-overexpressing metastatic breast cancer.