Ovarian germ cell tumors usually occur in teenage girls or young women and most often affect just one ovary. The ovaries are a pair of organs in the female reproductive system. They are in the pelvis, one on each side of the uterus (the hollow, pear-shaped organ where a fetus grows).
Is germ cell tumors common?
Germ cell tumors are rare. Germ cell tumors account for about 2 to 4 percent of all cancers in children and adolescents younger than age 20. Germ cell tumors can spread (metastasize) to other parts of the body. The most common sites for metastasis are the lungs, liver, lymph nodes, and central nervous system.
What are the risk factors for developing germ cell tumors?
Germ Cell Tumor – Childhood: Risk Factors
- Cryptorchidism. If a child has an undescended testicle, they have a higher risk of developing a testicular seminoma tumor. …
- Turner syndrome. …
- Intersex conditions, such as androgen insensitivity syndrome.
Are germ cell tumors hereditary?
The cause of germ cell tumors isn’t fully known. Some gene defects passed on from parents to children (inherited) may increase the risk for germ cell tumors. Some genetic syndromes can cause abnormal growth of the male and female reproductive systems.
How common is Dysgerminoma?
The most commonly occurring GCT is the dysgerminoma, which accounts for approximately 2% of all ovarian cancers. Although rare, dysgerminomas are important irrespective of incidence because they most commonly affect women of reproductive age (ie, < 30 y).
Are you born with germ cells?
That’s because as a baby develops before birth, germ cells move into place and become either eggs in the ovaries or sperm in the testicles. Sometimes, a group of germ cells grows in a way that’s not normal. A tumor forms. This usually happens in an ovary or testicle.
Are germ cell tumors curable?
Germ cell tumours generally respond very well to chemotherapy and most people are cured. Even cancers that have spread are still very treatable with chemotherapy.
What is the survival rate of germ cell tumor?
The 5-year survival rate for teens ages 15 to 19 is 93%. The survival and cure rates also depend on several factors, including the stage of the disease. The cure rate for children with a stage I or stage II germ cell tumor is 90%. The cure rate for a stage III tumor is 87%.
What does seminoma look like?
At gross pathologic analysis, classic seminoma is typically tan to pale yellow, solid, and fleshy. It is most often a well-circumscribed mass. Frequently, small foci of hemorrhage and necrosis are present (16).
Do germ cell tumors grow fast?
There are two types of germ cell tumors that start in the gonads, or reproductive organs: seminomas, which are slower-growing, and nonseminomas, which are faster-growing tumors.
Can germ cell tumors come back?
How do providers treat benign (noncancerous) ovarian germ cell tumors? Healthcare providers remove benign tumors surgically. Sometimes, they need to remove the ovary (or part of the ovary) when removing the tumor. Benign tumors rarely grow back after providers remove them.
What are the causes of germ cell tumor?
What Causes Germ Cell Tumors?
- birth defects that involve the central nervous system, genitals, urinary tract, and spine.
- genetic conditions that cause missing or extra sex chromosomes.