How long should I take letrozole for breast cancer?

Most people are given letrozole for 5 years, but some will take it for up to 10 years. Common side effects can be like menopause symptoms and include hot flushes, difficulty sleeping, tiredness and low mood. Side effects usually improve after a few months as your body gets used to the medicine.

Why do you take letrozole for 5 years?

A new trial suggests that extending aromatase inhibitor therapy with letrozole for an additional 5 years may improve disease-free survival and reduce the rate of new contralateral breast cancers in this group of postmenopausal women. An extra 5 years of letrozole did not, however, improve overall survival in the MA.

Should I take letrozole for 10 years?

A study has reported that taking a type of hormone therapy for 10 years could reduce the risk of breast cancer returning, compared to taking it for a shorter length of time.

What happens when you stop taking letrozole?

Stopping letrozole

Some people worry about stopping their treatment, but there’s evidence that letrozole continues to reduce the risk of breast cancer coming back for many years after you stop taking it. However, not taking the drug for the recommended time may increase the risk of your breast cancer coming back.

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How effective is letrozole for breast cancer?

In all women, letrozole significantly reduced the overall risk of recurrence by 42% (HR: 0.58; 95% CI: 0.45–0.76; p < 0.001) and developing distant metastasis by 40% (HR: 0.60; 95% CI: 0.43–0.84; p < 0.002) compared with placebo [17].

Should I stop taking letrozole after 5 years?

by Drugs.com

Letrozole is usually taken for 5 years, but may be recommended for up to 10 years depending on individual circumstances. The American Society of Clinical Oncology (ASCO) recommends that 10 years should be the maximum duration of therapy, based on their 2019 clinical practice guideline update.

How long should you be on letrozole?

Most people are given letrozole for 5 years, but some will take it for up to 10 years. Common side effects can be like menopause symptoms and include hot flushes, difficulty sleeping, tiredness and low mood. Side effects usually improve after a few months as your body gets used to the medicine.

Does letrozole increase survival?

Women who received letrozole alone also had better overall survival at 8 years than women receiving tamoxifen alone (83.4 versus 81.2 percent).

Does letrozole cause liver damage?

Liver injury attributed to letrozole is usually mild and self-limited, typically a transient, asymptomatic elevation in serum enzymes. Cases of acute liver failure have been reported in women on other aromatase inhibitors, but not specifically letrozole.

Why was letrozole banned?

That study also found no significant difference in the rate of overall abnormalities, but found that congenital cardiac anomalies was significantly higher in the clomiphene group compared to the letrozole group. Despite this, India banned the usage of letrozole in 2011, citing potential risks to infants.

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Is it OK to take letrozole every other day?

The dose of Femara in patients with cirrhosis and severe hepatic dysfunction should be reduced by 50% [see WARNINGS AND PRECAUTIONS]. The recommended dose of Femara for such patients is 2.5 mg administered every other day.

What are the worst side effects of letrozole?

Letrozole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • hot flushes.
  • night sweats.
  • nausea.
  • vomiting.
  • loss of appetite.
  • constipation.
  • diarrhea.
  • heartburn.

Does memory improve after stopping letrozole?

The substudy showed significant improvement in cognition after cessation of therapy. The finding was consistent across all cognitive tasks and consistent in women taking either tamoxifen or letrozole at the 5-year time point. The observed effect size was moderate for the change in overall cognition.

Can cancer return while taking letrozole?

Almost three years after the study ended, those who began letrozole had only a 2 percent risk of tumor recurrence, compared with almost 5 percent in those choosing no treatment.

What type of breast cancer is most likely to recur?

Among patients who were recurrence-free when they stopped endocrine therapy after five years, the highest risk of recurrence was for those with originally large tumors and cancer that had spread to four or more lymph nodes. These women had a 40 percent risk of a distant cancer recurrence over the next 15 years.