You asked: Which variable has the greater association with increased risk of breast cancer?

Age is the most significant risk factor for breast cancer. The disease is rare in women younger than 25 years, and the incidence increases with increasing age, reaching a plateau in women aged 50-69 years. In 2019, 50% of all new cases of invasive breast cancer occurred in women 50 to 69 years of age.

What factor is associated with an increased risk of breast cancer?

The risk for breast cancer increases with age; most breast cancers are diagnosed after age 50. Genetic mutations. Inherited changes (mutations) to certain genes, such as BRCA1 and BRCA2. Women who have inherited these genetic changes are at higher risk of breast and ovarian cancer.

What risk factors are associated with an increased risk of cancer?

General risk factors for cancer include:

  • Older age.
  • A personal or family history of cancer.
  • Using tobacco.
  • Obesity.
  • Alcohol.
  • Some types of viral infections, such as human papillomavirus (HPV)
  • Specific chemicals.
  • Exposure to radiation, including ultraviolet radiation from the sun.
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Is Nulliparity a risk factor for breast cancer?

It has been known for decades that nulliparity is associated with an increased risk for certain reproductive malignancies, including breast, ovarian and uterine cancers.

Which client is at greatest risk for the development of a cancerous breast lesion?

After gender, age is the most influential risk factor for developing breast cancer. Women younger than age 40 account for only 4.7 percent of invasive breast cancer diagnoses and only 3.6 percent of in situ breast cancer diagnoses. Over 70 percent of all breast cancer diagnoses are made in women who are 50 or older.

What environmental factors can cause cancer?

Environmental factors that cause cancer

  • Lifestyle factors (nutrition, tobacco use, physical activity)
  • Natural occurring exposures (ultraviolet light, radon gas, infectious agents)
  • Medical treatments (radiation and medicine)
  • Workplace and household exposures.
  • Pollution.

Which of the mutations described have the potential to cause cancer?

The most commonly mutated gene in people with cancer is p53 or TP53. More than 50% of cancers involve a missing or damaged p53 gene. Most p53 gene mutations are acquired. Germline p53 mutations are rare, but patients who carry them are at a higher risk of developing many different types of cancer.

What are the genetic risk factors for cancer?

Inherited genetic mutations play a major role in about 5 to 10 percent of all cancers. Researchers have associated mutations in specific genes with more than 50 hereditary cancer syndromes, which are disorders that may predispose individuals to developing certain cancers.

What is unopposed estrogen?

The use of unopposed estrogen therapy (estrogen therapy alone without progesterone) is associated with an increase in the risk of endometrial cancer (cancer of the lining of the uterus). However, by taking the hormone progestogen along with estrogen, the risk of endometrial cancer is reduced substantially.

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Which of the following are the most important and clinically useful risk factor for breast cancer?

Age is the most significant risk factor for breast cancer. The disease is rare in women younger than 25 years, and the incidence increases with increasing age, reaching a plateau in women aged 50-69 years.

Does nulliparity increase risk of endometrial cancer?

Background. Nulliparity is associated with an increased risk of endometrial cancer. Less clear is whether nulliparity modifies the association between other established hormone-related risk factors.

What happens when BRCA1 is mutated?

Women born with a mutated copy of BRCA1 have been shown to have lifetime risks of breast cancer between 50 and 90 percent, a wide range. They also have high, but variable, risks of ovarian and other cancers.

What is diethylstilbestrol used for?

What is DES? Diethylstilbestrol (DES) is a synthetic form of the female hormone estrogen. It was prescribed to pregnant women between 1940 and 1971 to prevent miscarriage, premature labor, and related complications of pregnancy (1).

What type of gene is BRCA1?

BRCA1 and BRCA2 are two genes that are important to fighting cancer. They are tumor suppressor genes. When they work normally, these genes help keep breast, ovarian, and other types of cells from growing and dividing too rapidly or in an uncontrolled way.