Borderline ovarian tumours are abnormal cells that form in the tissue covering the ovary. They are not cancer and are usually cured with surgery.
Are serous borderline tumors staged?
Results: The majority (78%) of ovarian borderline tumors primarily were encountered and staged by general obstetrician-gynecologists. Overall, 66% of patients had at least 1 staging biopsy performed.
What is a serous borderline tumor of the ovary?
Serous borderline tumor represents a group of noninvasive tumor of the ovary bridging between benign serous cystadenoma and serous carcinoma. They are commonly seen in younger women and usually have an excellent outcome but seldom show local recurrence (J. F. Leake et al. 1991).
Are borderline ovarian tumors hereditary?
Approximately 10% of all epithelial ovarian cancers are known to be hereditary with hereditary breast and ovarian cancer (HBOC) accounting for approximately 90% of cases; the remaining 10% are attributable to Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC).
How common are borderline ovarian tumors?
Borderline ovarian tumors comprise about 15%–20% of all epithelial ovarian malignancies [2, 3] with an incidence of 1.8–4.8 per 100,000 women per year [3–5].
Do borderline tumors spread?
Observation is often recommended for borderline tumors because they grow very slowly and even when they spread they are rarely fatal.
Can borderline ovarian tumors spread?
Borderline ovarian tumors, often referred to as “low malignant potential” tumors, are not invasive but also not completely benign. Their behavior can also vary based on microscopic features, and some are more likely to recur or spread than others.
What is the histologic feature that differentiates borderline ovarian tumors from invasive ovarian cancers?
Increase in nuclear/cytoplasmic ratio. Slight to complex branching of epithelial papillae and pseudopapillae. Epithelial budding and cell detachment into the lumen. No destructive stromal invasion – A major component in differentiating malignant from borderline tumors.
What is serous carcinoma?
Uterine serous carcinoma (USC), also termed USC or uterine papillary serous carcinoma (UPSC), is a type of endometrial cancer which is rarely found among postmenopausal women.1 It is usually diagnosed with endometrial biopsy from patients with postmenopausal uterine bleeding.
Are borderline tumors malignant?
Preoperatively, borderline tumors are often presumed to be either benign or malignant ovarian masses; however, as with other ovarian masses, staging is performed surgically.
Can a benign ovarian tumor become malignant?
Benign ovarian tumors usually grow slowly and rarely become malignant. They include the following: Benign cystic teratomas: These tumors are also called dermoid cysts because although derived from all 3 germ cell layers, they consist mainly of ectodermal tissue.
Is ovarian carcinoma benign or malignant?
Most ovarian germ cell tumors are benign, but some are cancerous and may be life threatening. Less than 2% of ovarian cancers are germ cell tumors. Overall, they have a good outlook, with more than 9 out of 10 patients surviving at least 5 years after diagnosis. There are several subtypes of germ cell tumors.