The use of thiazide diuretics was associated with an increased risk of squamous cell carcinoma (adjusted odds ratio (aOR), 1.86; 95% confidence interval (CI), 1.23 – 2.80) and marginally increased risk of basal cell carcinoma (aOR, 1.19; 95% CI, 1.02 – 1.38) and malignant melanoma (aOR, 1.14; 95% CI, 1.01 – 1.29).
Can hydrochlorothiazide cause cancer?
The Food and Drug Administration (FDA) recently recommended a label change for the prescription diuretic, hydrochlorothiazide. The FDA approved the label change to reflect recent findings that show patients who use hydrochlorothiazide have a higher risk of developing non-melanoma skin cancer.
Does hydrochlorothiazide cause squamous cell carcinoma?
Hydrochlorothiazide is photosensitizing and has been linked to lip cancer. We found a dose-dependent increased risk of nonmelanoma skin cancer, particularly squamous cell carcinoma, among users of hydrochlorothiazide.
Is there a black box warning for hydrochlorothiazide?
This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous. You shouldn’t take this drug if you’re pregnant or plan to become pregnant. This drug can harm or end your pregnancy.
Does hydrochlorothiazide cause lip cancer?
No association with lip cancer was seen with use of other diuretics or nondiuretic antihypertensives. Assuming causality, we estimated that 11% of the SCC lip cancer cases could be attributed to hydrochlorothiazide use. Conclusions: Hydrochlorothiazide use is strongly associated with an increased risk of lip cancer.
Do all diuretics cause skin cancer?
Especially, HCTZ or HCTZ combination medications were significantly associated with an increased risk of SCC without significant heterogeneity among the studies. In a recent meta-analysis by Gandini et al , there was no significant association between thiazide diuretics and skin cancers.
What are the long term effects of taking hydrochlorothiazide?
If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks.
Does hydrochlorothiazide cause melanoma?
In contrast, hydrochlorothiazide was not associated with an increased risk of BCC (HR 1.01, 95% CI 0.91-1.13) or melanoma (HR 0.82, 95% CI 0.63-1.08), with no evidence of duration- or dose-response relationships.
Is there an alternative to hydrochlorothiazide?
Hydrochlorothiazide (HCTZ) is one of the most commonly prescribed generic medications to lower blood pressure and protect people from these issues, but it turns out there’s an alternative that might be more effective—chlorthalidone.
What are the side effects from hydrochlorothiazide?
The more common side effects that can occur with hydrochlorothiazide include:
- blood pressure that’s lower than normal (especially when standing up after sitting or lying down)
- erectile dysfunction (trouble getting or keeping an erection)
- tingling in your hands, legs, and feet.
Is lisinopril the same as hydrochlorothiazide?
Lisinopril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily. Hydrochlorothiazide is a “water pill” (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water. This product is used when one drug is not controlling your blood pressure.
What is generic for hydrochlorothiazide?
Microzide (hydrochlorothiazide) is a diuretic (water pill) prescribed for lowering blood pressure (hypertension) and accumulation of fluid (edema). Microzide is available as a generic drug.
Is hair loss a side effect of lisinopril?
ACE inhibitors are a class of medications used to treat high blood pressure. They include the medicines, captopril and lisinopril. Both of the drugs have been known to cause hair loss—but only in around 1% of patients taking them.
What medications cause skin cancer?
The findings showed that certain types of high blood pressure drugs — known as thiazide diuretics — were associated with higher rates of keratinocyte skin cancers, including basal cell carcinoma, squamous cell carcinoma, advanced keratinocyte carcinoma and melanoma.
Why should you avoid the sun when taking hydrochlorothiazide?
Hydrochlorothiazide is a prescription drug used to treat high blood pressure and swelling. It is known to make skin more sensitive to ultraviolet radiation and sunlight, meaning patients can get sunburned more easily.
What is the blood pressure medicine that causes cancer?
Two types of blood pressure medications sold by Lupin Pharmaceuticals Inc. were voluntarily recalled by the manufacturer after routine ingredient testing detected high levels of N-nitrosoirbesartan, a potentially cancer-causing impurity.