How is ovarian clear cell carcinoma treated?

The standard surgical treatment of patients with EOC is based on hysterectomy, bilateral salpingo-oophorectomy and partial omentectomy with peritoneal sampling and lymphadenectomy, and cytoreductive surgery is added especially for advanced cases.

Does Chemo work on clear cell carcinoma?

Ovarian clear cell carcinomas (OCCC) are relatively resistant to platinum-based chemotherapy with lower response rates and shorter progression-free survival compared with high-grade serous cancers.

Is clear cell ovarian carcinoma aggressive?

Clear cell cancers are more likely to present at an early stage, as it tends to present with a large pelvic mass, or deep vein thrombosis (blood clotting). However, they are also one of the more aggressive types of ovarian cancer and progress quickly.

Is clear cell carcinoma curable?

Patients with clear cell renal cell carcinoma (CCRCC) tend to have a worse prognosis than patients with other histologic subtypes of RCC, with 5-year disease-specific survival rates of 50-69%, compared with 67-87% for papillary RCC and 78-87% for chRCC.

What is clear cell carcinoma ovary?

Ovarian clear-cell carcinoma is an uncommon subtype of epithelial ovarian carcinoma. It carries a generally poor prognosis because of its resistance to standard treatment and metastatic spread to vital organs. Metastasis to the breast is rare and bilateral breast metastasis is unreported.

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What is the best treatment for clear cell carcinoma?

Targeted therapy: Targeted therapy targets the changes in cancer cells that help them grow, divide, and spread. Some targeted therapies that are used to treat clear cell renal carcinoma include cabozantinib, axitinib, sunitinib, sorafenib, and pazopanib.

What is a clear cell?

In histology, a clear cell is a cell that shows a clear cytoplasm when stained with hematoxylin and eosin (H&E).

Is clear cell carcinoma fatal?

When diagnosed beyond FIGO (International Federation of Gynecology and Obstetrics) stage 1 patients usually have a poor prognosis. If the malignant tumors metastasize and spread throughout the body then they could potentially be fatal.

What causes ovarian clear cell carcinoma?

The genes that increase the risk of ovarian cancer include BRCA1 and BRCA2. These genes also increase the risk of breast cancer. Several other gene changes are known to increase the risk of ovarian cancer, including gene changes associated with Lynch syndrome and the genes BRIP1, RAD51C and RAD51D.

Is ovarian clear cell carcinoma genetic?

Epidemiological studies have suggested a genetic predisposition for ovarian cancer, which can run in families and also favors second primary tumors (1,2). High-grade SC is the most common subtype of ovarian cancer with approximately 70% of cases and CCC occurs at a frequency of approximately 12% (3).

How fast does clear cell carcinoma grow?

Clear cell carcinoma (0.86 cm/year) tended to grow faster than papillary cell carcinoma (0.28 cm/year) (P = 0.066).

Why is clear cell carcinoma clear?

CCCs make up 5%–25% of all ovarian cancers, making them the most common type after the HGSCs [46]. They are so named because the cancer cells typically have abundant clear cytoplasm due to the presence of intracytoplasmic glycogen, which is lost during processing (Fig. 4).

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Is Stage 1 RCC curable?

Patients with stage I renal cell cancer are curable with surgical removal of the cancer, however some cancers may effectively be managed with a “watch and wait” program of “active surveillance.” During active surveillance low risk risk cancers are followed with periodic imaging studies and surgical intervention is used …

What is clear cell Acanthoma?

Clear cell acanthoma is an uncommon type of benign epithelial tumor. Typically, it is a solitary lesion found on the lower limbs. It presents as a nodule or small plaque with slow and well-defined growth.

Are all cancers carcinomas?

Not all cancers are carcinoma. Other types of cancer that aren’t carcinomas invade the body in different ways. Those cancers begin in other types of tissue, such as: Bone.

What is a yolk sac tumor?

Listen to pronunciation. (yok sak TOO-mer) A rare type of cancer that begins in germ cells (cells that form sperm or eggs). Yolk sac tumors occur most often in the ovary or testicle, but they may also occur in other areas of the body, such as the chest, abdomen, or brain.