The majority of hereditary uterine cancer is due to Lynch syndrome, which is caused by a mutation in one of five genes: MLH1, MSH2, MSH6, PMS2 and EPCAM. A person who has a mutation in one of these genes has increased lifetime risks for colon, uterine, ovarian, stomach, skin and other cancers.
Does uterine cancer run in families?
About 5 percent of uterine cancers are linked to hereditary factors. If several members of your family have had endometrial cancer or Lynch syndrome (also known as hereditary non-polyposis colorectal cancer) you may be a candidate for genetic testing.
What is the main cause of uterine cancer?
Uterine cancer usually happens after menopause. It is more common in women who have obesity. You also have a higher risk if you took estrogen-only hormone replacement therapy (menopausal hormone therapy) for many years. Tests to find uterine cancer include a pelvic exam, imaging tests, and a biopsy.
What cancers have a hereditary component?
Some cancers that can be hereditary are:
- Breast cancer.
- Colon cancer.
- Prostate cancer.
- Ovarian cancer.
- Uterine cancer.
- Melanoma (a type of skin cancer)
- Pancreatic cancer.
What is the rarest form of uterine cancer?
Uterine leiomyosarcoma is an extremely rare form of cancer, estimated to occur in 6 out of every 1,000,000 women in the United States each year. The average age at diagnosis is 51. Uterine leiomyosarcomas account for 1-2 percent of all malignant tumors of the uterus.
Who is most likely to get uterine cancer?
Uterine cancer most often occurs in women over 50. The average age at diagnosis is 60. Uterine cancer is not common in women younger than 45. Obesity.
Will a hysterectomy cure uterine cancer?
The most successful treatment for early cancer is total hysterectomy with bilateral salpingo-oophorectomy, in which the uterus, cervix, ovaries, and fallopian tubes are removed.
Where does uterine cancer spread first?
In general, uterine cancer can metastasize to the rectum or bladder. Other areas where it may spread include the vagina, ovaries and fallopian tubes. This form of cancer is typically slow growing and often detected before it has spread to more distant areas of the body.
What were your first signs of endometrial cancer?
The most likely symptoms are:
- Abnormal vaginal bleeding or discharge, which occurs in nine out of 10 women with endometrial cancer. …
- Vaginal discharge that may range from pink and watery to thick, brown, and foul smelling.
- Difficult or painful urination.
- An enlarged uterus, detectable during a pelvic exam.
What percentage of cancers are genetic?
Inherited genetic mutations play a major role in about 5 to 10 percent of all cancers. Researchers have associated mutations in specific genes with more than 50 hereditary cancer syndromes, which are disorders that may predispose individuals to developing certain cancers.
How many cancers are hereditary?
Only about 5% to 10% of all cancers result directly from gene defects (called mutations) inherited from a parent. This information is about those cancers.
What is Lynch syndrome?
Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common cause of hereditary colorectal (colon) cancer. People with Lynch syndrome are more likely to get colorectal cancer and other cancers, and at a younger age (before 50), including.
What are the warning signs of uterine cancer?
Signs of Uterine Cancer
- Unusual vaginal bleeding or spotting. …
- Abnormal vaginal discharge that may be bloody or non-bloody.
- Any bleeding from the vagina after menopause.
- A mass or tumor in your lower abdomen (belly) that you can feel.
- Pain in your pelvic area or lower abdomen (belly)
- Losing weight without trying.
How fast does uterine cancer grow?
If left untreated, endometrial cancer can spread to the bladder or rectum, or it can spread to the vagina, fallopian tubes, ovaries, and more distant organs. Fortunately, endometrial cancer grows slowly and, with regular checkups, is usually found before spreading very far.
Can endometrial cancer come back after hysterectomy?
Endometrial cancer is most likely to recur in the first three years after the initial treatment, though late recurrence is also possible. If you would like to speak with a physician at Moffitt Cancer Center about endometrial cancer or undergoing a hysterectomy, we invite you to request an appointment.