Question: Can telomerase cure cancer?

Although the inhibition of telomerase may strip some cancers of their immortality, cancers are still viable and largely unaffected by the loss of telomerase.

Does telomerase help cancer?

Telomerase has been a prime target for the development of effective therapeutics against cancer as it is expressed in the majority of cancer types as well as in cancer stem or stem-like cells.

How can telomerase treat cancer?

Due to telomerase inhibition, activity, or expression, these drugs might kill tumor cells by allowing telomeres to shrink or by provoking apoptosis. First of all, this process might have a chance to be cell-specific without serious side effects (Fig. 1).

What role can telomerase play in cancer?

Cancer cells often avoid senescence or cell death by maintaining their telomeres despite repeated cell divisions. This is possible because the cancer cells activate an enzyme called telomerase, which adds genetic units onto the telomeres to prevent them from shortening to the point of causing senescence or cell death.

Can telomerase be a potential target for cancer therapy?

Telomerase is an attractive target antigen for cancer immunotherapy because it is expressed almost universally in human cancers and is functionally required to sustain malignant tumor long-term growth [87].

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Is telomerase good or bad?

Too much telomerase can help confer immortality onto cancer cells and actually increase the likelihood of cancer, whereas too little telomerase can also increase cancer by depleting the healthy regenerative potential of the body.

How is telomerase activated in cancer?

The regulation of telomerase activity in human cells plays a significant role in the development of cancer. Telomerase is tightly repressed in the vast majority of normal human somatic cells but becomes activated during cellular immortalization and in cancers.

Do all cancer cells express telomerase?

Cancer cells are characterized by high telomerase activity, which enables cells to divide indefinitely. Telomerase is active in 85–95% of cancers (3,4). The exception is cancer cells possessing an active Alternative Lengthening of Telomeres (ALT) pathway.

What is the best telomere supplement?

TA-65MD® nutritional supplements have been proven to activate telomerase and lengthen telomeres. They should be taken as part of an overall health and wellness regimen. TA-65MD® supplements have been proven safe and effective in more than a decade of studies and in use by people worldwide.

What are 90% of human cancers due to?

The fact that only 5–10% of all cancer cases are due to genetic defects and that the remaining 90–95% are due to environment and lifestyle provides major opportunities for preventing cancer.

Do telomeres and telomerase show promise in the fight against cancer?

Due to its high activity in the majority of cancers and low expression in somatic cells, telomerase and the telomere as a whole are very promising targets [2,10]. Continued studies on telomeres may provide promising avenues of research in the development of novel anticancer therapeutics.

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What happens if you inhibit telomerase?

Inhibition of telomerase prevents the maintenance of telomere length in telomerase-positive cells. As a result, telomerase may shorten, leading to eventual replicative senescence or apoptosis.

What could be a negative effect of telomerase activity?

A final concern is that telomerase inhibitors could lead to increased genomic instability in surviving cells (Hackett and Greider, 2002, Harrington and Robinson, 2002), leading to more advanced or aggressive tumors.