Burkitt lymphoma (BL) is a highly malignant B-cell tumor associated with Epstein-Barr Virus (EBV) infection. Although BL can be effectively treated in adults and children, leading to high survival rates, its ability to mask itself from the immune system makes BL an intriguing disease to study.
What pathogen causes Burkitt’s lymphoma?
Burkitt’s lymphoma, particularly the endemic form that is common in Africa, is associated with the Epstein-Barr Virus (EBV) in nearly 100% of cases. In the sporadic forms that occur in Western countries, EBV is present in approximately 30% of cases and in 40% of immunodeficiency-associated cases.
Which virus is associated with Burkitt lymphoma?
Epstein–Barr virus (EBV) is etiologically linked to endemic Burkitt lymphoma (BL), but its contribution to lymphomagenesis, versus that of the chromosomal translocation leading to c-myc gene deregulation, remains unclear.
Which of the following mutation causes Burkitt’s lymphoma?
Burkitt lymphoma results from chromosome translocations that involve the Myc gene. A chromosome translocation means that a chromosome is broken, which allows it to associate with parts of other chromosomes. The classic chromosome translocation in Burkitt lymophoma involves chromosome 8, the site of the Myc gene.
What chromosome is affected by Burkitt’s lymphoma?
Burkitt lymphoma (BL) is a highly aggressive B cell neoplasm characterized by the translocation and deregulation of the MYC gene on chromosome 8.
Is Burkitt lymphoma caused by Epstein-Barr virus?
In particular, some cases of Burkitt lymphoma (BL) are caused by Epstein-Barr Virus (EBV), the first human tumor virus to be discovered. In the decades since the discovery of EBV, we have learned that contributions that EBV makes to the formation and maintenance of Burkitt lymphomas are complex.
What is EBV virus?
Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the herpes virus family. It is one of the most common human viruses. EBV is found all over the world. Most people get infected with EBV at some point in their lives. EBV spreads most commonly through bodily fluids, primarily saliva.
How does Epstein-Barr virus causes Burkitt lymphoma?
One observation that favored the carcinogenic role of EBV in Burkitt’s lymphoma was the finding that EBV was an extremely potent transforming virus in culture for the same cell type that develops into Burkitt’s lymphoma, the B lymphocyte , being able to convert >50% of B cell into continuously proliferating, …
What happens in Burkitt lymphoma?
Burkitt lymphoma is a form of non-Hodgkin’s lymphoma in which cancer starts in immune cells called B-cells. Recognized as a fast growing human tumor, Burkitt lymphoma is associated with impaired immunity and is rapidly fatal if left untreated.
Is Burkitt’s lymphoma a mutation?
Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other genetic mutations to the disease is largely unknown. Here, we describe the first completely sequenced genome from a Burkitt lymphoma tumor and germline DNA from the same affected individual.
What is endemic Burkitt lymphoma?
Endemic Burkitt lymphoma (eBL) is an aggressive B cell non-Hodgkin lymphoma associated with antigenic stimulation from Plasmodium falciparum malaria. Whether eBL risk is related to malaria parasite density is unknown.
What is Burkitt leukemia?
Burkitt’s leukemia is the name that doctors give to Burkitt’s lymphoma, which occurs when tumor cells develop in the bone marrow and bloodstream. Burkitt’s lymphoma is a rare type of non-Hodgkin lymphoma. It is a blood cancer that affects B lymphocytes and how well a person can fight infections.
Where is the Philadelphia chromosome found?
The Philadelphia chromosome or Philadelphia translocation (Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myeloid leukemia (CML) cells).
Who is Burkitt?
Burkitt lymphoma is a cancer of the lymphatic system, particularly B lymphocytes found in the germinal center. It is named after Denis Parsons Burkitt, the Irish surgeon who first described the disease in 1958 while working in equatorial Africa.
|Specialty||Hematology and oncology|